Cooke M M, Jackson R, Coleman J D, Alley M R
Department of Veterinary Pathology and Public Health, Massey University, Palmerston North, New Zealand.
N Z Vet J. 1995 Dec;43(7):315-21. doi: 10.1080/00480169./1995.35912.
The gross and microscopic lesions due to Mycobacterium bovis infection are described in 73 brushtail possums (Trichosurus vulpeculu) from population studies and from 11 terminally ill possums. Subcutaneous lesions were suppurative in nature, often discharging through sinuses to the exterior. Histologically, the smallest lesions comprised focal aggregations of macrophages with angulated cytoplasmic boundaries occasionally containing acid-fast organisms. Larger lesions were pyogranulomatous, with extensive necrosis, caseation and large numbers of intra- and extra-cellular acid-fast organisms. Few multinucleate giant cells were seen and fibroplasia was rare. Mineralisation was recorded in tuberculous lymph nodes from only two possums. Histological evidence of haematogenous and lymphatic spread was seen in some cases.
通过种群研究，对73只帚尾袋貂（Trichosurus vulpeculu）以及11只濒死袋貂中由牛分枝杆菌感染引起的大体和微观病变进行了描述。皮下病变本质上是化脓性的，常常通过窦道向外排出。组织学上，最小的病变由巨噬细胞的局灶性聚集组成，巨噬细胞有角状的细胞质边界，偶尔含有抗酸菌。较大的病变为脓性肉芽肿，伴有广泛坏死、干酪样变以及大量细胞内和细胞外抗酸菌。很少见到多核巨细胞，纤维增生也很罕见。仅在两只袋貂的结核性淋巴结中记录到矿化现象。在一些病例中可见血行和淋巴扩散的组织学证据。
