Gravenmade E J, Vissink A
Department of Neurology, University of Groningen, Netherlands.
Neth J Med. 1992 Apr;40(3-4):117-24.
In this paper the basis of the oral features of Sjögren's syndrome is described and guidelines for proper management of these features are given. The most pronounced oral symptoms are a dry sensation in the mouth and difficulties with swallowing and speech. Furthermore, these patients do not sleep well and may complain about burning mucous membranes, rampant caries and candidosis. Rampant caries can be prevented by optimal oral hygiene and frequent applications of a fluoride gel. Prophylaxis of candidosis can be achieved by meticulous oral hygiene and removal of predisposing factors (e.g. poorly fitting dentures). It is only possible to treat the other oral signs of Sjögren's syndrome symptomatically, because damage of salivary-gland parenchyma is progressive and irreversible. In the early stages of Sjögren's syndrome, good results can be obtained by gustatory or pharmacological stimulation of the salivary secretion. In the more advanced stages, the patient has to resort to oral rinses and saliva substitutes, the majority of which are not satisfactory. Promising results have been obtained with mucin-containing lozenges.
本文描述了干燥综合征口腔特征的基础,并给出了这些特征的适当管理指南。最明显的口腔症状是口腔干燥、吞咽和言语困难。此外,这些患者睡眠不佳,可能会抱怨黏膜灼烧、猖獗性龋齿和念珠菌病。通过最佳口腔卫生和频繁应用氟化物凝胶可预防猖獗性龋齿。念珠菌病的预防可通过细致的口腔卫生和消除诱发因素(如不合适的假牙)来实现。干燥综合征的其他口腔症状只能对症治疗,因为唾液腺实质的损伤是进行性和不可逆的。在干燥综合征的早期阶段,通过味觉或药物刺激唾液分泌可取得良好效果。在更晚期阶段,患者不得不求助于口腔冲洗和唾液替代品,其中大多数并不令人满意。含黏蛋白含片已取得了有前景的结果。