Vissink A, Panders A K, Gravenmade E J, Vermey A
Scand J Rheumatol Suppl. 1986;61:270-3.
The most pronounced oral symptoms in Sjögren's syndrome are a dry sensation of the mouth and difficulties in swallowing and speech. Besides these patients do no sleep well and may complain about burning mucous membranes, rampant caries and candidosis. Rampant caries can be prevented by optimal oral hygiene and frequent applications of a neural 1% sodium fluoride gel. Prophylaxis of candidosis can be obtained by meticulous oral hygiene and removal of predisposing factors (e.g. poor dentures). For the other oral signs of Sjögren's syndrome only a symptomatic treatment is possible, because damage of salivary gland tissue is progressive and irreversible. Good results can be obtained by applying a mucin-containing saliva substitute, which has been shown to reduce the dry an burning sensation of the mouth as well as to improve chewing, swallowing, speech and sleeping. When applied by an atomizer it wets the oral cavity for about 30 min. A continuous wetting can be obtained using intra-oral artificial saliva reservoirs.
干燥综合征最明显的口腔症状是口腔干燥感以及吞咽和言语困难。除此之外，这些患者睡眠不佳，可能会抱怨黏膜灼烧感、猖獗性龋齿和念珠菌病。通过优化口腔卫生和频繁涂抹中性1%氟化钠凝胶可预防猖獗性龋齿。通过细致的口腔卫生和消除诱发因素（如假牙不合适）可预防念珠菌病。对于干燥综合征的其他口腔症状，仅能进行对症治疗，因为唾液腺组织的损伤是进行性且不可逆的。使用含黏蛋白的唾液替代品可取得良好效果，已证明其能减轻口腔的干燥和灼烧感，还能改善咀嚼、吞咽、言语和睡眠。通过喷雾器使用时，它可使口腔湿润约30分钟。使用口腔内人工唾液储存器可实现持续湿润。
