Chadwick C
Neuroepidemiology. 1992;11 Suppl 1:37-43. doi: 10.1159/000110959.
The purpose of this paper is to describe the design and methodology of this multicentre study of cognitive function and ageing, which is currently funded by the Medical Research Council (MRC) and the Department of Health for a period of 5 years. The study is designed to estimate and compare the prevalence and incidence of dementia in five centres in the United Kingdom, to examine the natural history of cognitive decline and dementia in the population and to evaluate the degree of disability associated with any decline. This will be achieved by the examination, twice, of the cognitive function of individuals aged 65 and over, with an interval of 2 years between the examinations. A 20% subsample, taken across the full range of cognitive function will be reviewed annually in more detail to chart the level of cognitive function and to ascertain a diagnosis of dementia. This represents the first systematic examination of different populations using a common methodology in the United Kingdom.
本文旨在描述这项关于认知功能与衰老的多中心研究的设计与方法，该研究目前由医学研究理事会（MRC）和卫生部资助，为期5年。该研究旨在估计和比较英国五个中心痴呆症的患病率和发病率，研究人群中认知衰退和痴呆症的自然史，并评估与任何衰退相关的残疾程度。这将通过对65岁及以上个体的认知功能进行两次检查来实现，两次检查之间间隔2年。每年将对认知功能全范围的20%子样本进行更详细的复查，以绘制认知功能水平并确定痴呆症的诊断。这是英国首次使用通用方法对不同人群进行系统检查。
