Wu Han-Ping, Lin Ching-Yuang, Chang Chin-Fu, Chang Yu-Jun, Huang Chin-Yi
Department of Emergency Medicine, Changhua Christian Hospital, Changhua, Taiwan.
Am J Emerg Med. 2005 Jul;23(4):449-53. doi: 10.1016/j.ajem.2004.10.013.
Determining the different cutoff values of C-reactive protein (CRP) on the basis of how long the patient's symptoms were present can be used to early predict acute appendicitis. We analyzed retrospectively from 2001 to 2004 the hospital records of 568 patients who underwent appendectomies for suspected appendicitis. Receiver operating characteristic analysis has shown that CRP measurement can increase the diagnostic accuracy in acute appendicitis. The cutoff values of CRP concentration taken as the first, second, and third days after onset of symptoms that distinguish acute appendicitis from other acute abdominal diseases were 1.5, 4.0, and 10.5 mg/dL, respectively; the values that distinguish perforated appendicitis from other acute abdominal diseases were 3.3 mg/dL (first day), 8.5 mg/dL (second day), and 12.0 mg/dL (third day). The different cutoff values of CRP concentration may serve as a useful predictive parameter in the early diagnosis of acute appendicitis on the first 3 days after the onset of symptoms.
根据患者症状出现的时长来确定C反应蛋白（CRP）的不同临界值，可用于早期预测急性阑尾炎。我们回顾性分析了2001年至2004年期间568例因疑似阑尾炎接受阑尾切除术患者的医院记录。受试者工作特征分析表明，CRP检测可提高急性阑尾炎的诊断准确性。症状出现后第1天、第2天和第3天，区分急性阑尾炎与其他急性腹部疾病的CRP浓度临界值分别为1.5、4.0和10.5mg/dL；区分穿孔性阑尾炎与其他急性腹部疾病的临界值分别为3.3mg/dL（第1天）、8.5mg/dL（第2天）和12.0mg/dL（第3天）。CRP浓度的不同临界值可作为症状出现后前3天急性阑尾炎早期诊断的有用预测参数。
