Hebbard G S, Salehi N, Gibson P R, Lichtenstein M, Andrews J T
Department of Gastroenterology, Royal Melbourne Hospital, Australia.
Nucl Med Commun. 1992 May;13(5):336-41. doi: 10.1097/00006231-199205000-00007.
In order to assess the value of 99Tcm-labelled-immunoglobulin G(99Tcm-IgG) in the assessment of the activity and distribution of intestinal inflammation in patients with inflammatory bowel disease (IBD), 99Tcm-IgG scans were performed in 18 patients. Patients were divided clinically into two groups, those with (ten patients) and those without (eight patients), intestinal inflammation. Disease activity and distribution were assessed by 111In-oxine granulocyte scanning and/or histological extent of inflammation at endoscopy or surgery in all patients with IBD and most of those without intestinal inflammation. In the assessment of the presence or absence of inflammation, a sensitivity of 80% and specificity of 87% were achieved. However, when the localization of intestinal inflammation was evaluated, only five of eight true positive scans were concordant with the distribution of intestinal inflammation as determined by other methods. Thus, significant areas of inflammation were missed in five of ten patients with IBD (two false negative, three incorrect localization of inflammation). Although 99Tcm-IgG scanning appears to have moderate sensitivity and acceptable specificity in the detection of intestinal inflammation, it performs poorly in assessing the distribution of inflammation and is, therefore, of little value in the assessment of patients with suspected or proven IBD.
为了评估99锝标记的免疫球蛋白G（99Tcm-IgG）在评估炎症性肠病（IBD）患者肠道炎症的活性和分布方面的价值，对18例患者进行了99Tcm-IgG扫描。患者在临床上被分为两组，有肠道炎症的患者（10例）和无肠道炎症的患者（8例）。通过111铟-氧粒细胞扫描和/或所有IBD患者以及大多数无肠道炎症患者在内镜检查或手术时的组织学炎症范围来评估疾病的活性和分布。在评估炎症的有无时，灵敏度达到80%，特异性达到87%。然而，在评估肠道炎症的定位时，8例真阳性扫描中只有5例与通过其他方法确定的肠道炎症分布一致。因此，10例IBD患者中有5例遗漏了显著的炎症区域（2例假阴性，3例炎症定位错误）。虽然99Tcm-IgG扫描在检测肠道炎症方面似乎具有中等灵敏度和可接受的特异性，但在评估炎症分布方面表现不佳，因此在评估疑似或确诊IBD患者时价值不大。
