Relyveld E H, Henocq E, Bizzini B
Dev Biol Stand. 1979;43:33-7.
Adverse reactions to diphtheria and tetanus toxoids have frequently been reported. The cause of these reactions has been attributed to different factors, including sensitization by prior vaccination. However, this explanation does not hold for primary vaccination. In this case, undesirable reactions to diphtheria toxoid are most likely due to bacterial cellular fractions present in the vaccines. In fact, we were able to demonstrate that fortuitous contact with atoxigenic diphtheria strains can induce sensitization. Consequently, vaccination should be carried out with highly purified toxoids, so as to prevent untoward reactions due to the presence of impurities. It is also preferable to detoxify purified toxins, rather than to purify crude toxoids.
白喉和破伤风类毒素的不良反应屡有报道。这些反应的原因归因于不同因素，包括既往接种疫苗导致的致敏。然而，这种解释不适用于初次接种。在这种情况下，对白喉类毒素的不良反应很可能是由于疫苗中存在的细菌细胞成分。事实上，我们能够证明偶然接触无毒力白喉菌株可诱导致敏。因此，应使用高度纯化的类毒素进行接种，以防止因杂质存在而产生的不良反应。对纯化毒素进行解毒也比纯化粗制类毒素更为可取。
