Recker Robert R, Barger-Lux M Janet
Creighton University School of Medicine, 601 North 30th Street, Suite 5766, Omaha, NE 68131, USA.
Curr Osteoporos Rep. 2004 Sep;2(3):97-100. doi: 10.1007/s11914-004-0017-z.
This paper outlines information from recent publications that aid our understanding of bone quality in relation to osteoporosis. In practical terms, bone quality designates the properties of bone that contribute to strength but are not assessed by bone densitometry. While osteoporosis is still defined in terms of bone density, the limitations of this approach, long questioned, have become indisputable. In parallel, the results of treatment trials of antiresorptive agents demonstrate that bone density is a flawed surrogate for bone fragility and a weak indicator of antifracture efficacy. The case for emphasizing bone turnover in assessing fracture risk, has become increasingly strong, and a redefinition of osteoporosis on this basis may well occur. New technologies for studying bone microstructure and matrix composition, merging with sophisticated biomechanical assessments, are advancing our ideas regarding bone "damageability" and its effects over time.
本文概述了近期出版物中的信息，这些信息有助于我们理解与骨质疏松症相关的骨质量。实际上，骨质量指的是有助于骨骼强度但无法通过骨密度测量评估的骨骼特性。虽然骨质疏松症仍根据骨密度来定义，但这种长期受到质疑的方法的局限性已变得无可争议。与此同时，抗吸收药物治疗试验的结果表明，骨密度是骨脆性的一个有缺陷的替代指标，也是抗骨折疗效的一个弱指标。在评估骨折风险时强调骨转换的理由越来越充分，基于此对骨质疏松症进行重新定义很可能会发生。研究骨微观结构和基质组成的新技术，与先进的生物力学评估相结合，正在推动我们对骨“易损性”及其随时间的影响的认识。
