de Silva H Asita, Gunatilake Saman B, Johnston Carole, Warden Donald, Smith A David
Department of Pharmacology, Faculty of Medicine, University of Kelaniya, Sri Lanka.
Exp Aging Res. 2005 Jul-Sep;31(3):345-54. doi: 10.1080/03610730590948221.
The authors studied the association of Alzheimer's disease (AD) with total plasma homocysteine (tHcy) and apolipoprotein E (apoE) genotype, and the usefulness of measuring medial temporal lobe thickness (MTL) thickness for the diagnosis of AD in Sri Lankan patients. Using criteria of the NINCDS-ADRDA, 23 AD patients and 21 controls were recruited. All underwent MTL-oriented computed tomographic (CT) scans, measurement of plasma tHcy, and apoE genotyping. Mean plasma tHcy was significantly higher in AD patients than controls (p=.001). This association was independent of age, sex, body mass index (BMI), serum folate and vitamin B12, and serum creatinine. The frequency of apoE4 allele was significantly higher (p=.003) in AD patients, and the adjusted odds ratio of AD for the presence of one or more apoE4 alleles compared with none was 10.39 (95% CI 1.77-61.10; p=.010). The mean minimum MTL thickness was significantly higher in control subjects compared to that of AD patients (p<.001). This first report of apoE4, plasma tHcy, MTL thickness, and AD from Sri Lanka shows that high plasma tHcy, the presence of apoE4 allele, and MTL atrophy are associated with AD.
作者研究了阿尔茨海默病（AD）与血浆总同型半胱氨酸（tHcy）和载脂蛋白E（apoE）基因型的关联，以及测量内侧颞叶厚度（MTL）对斯里兰卡患者AD诊断的有用性。根据NINCDS-ADRDA标准，招募了23例AD患者和21例对照。所有受试者均接受了以MTL为导向的计算机断层扫描（CT）、血浆tHcy测量和apoE基因分型。AD患者的平均血浆tHcy显著高于对照组（p = 0.001）。这种关联独立于年龄、性别、体重指数（BMI）、血清叶酸和维生素B12以及血清肌酐。AD患者中apoE4等位基因的频率显著更高（p = 0.003），与无apoE4等位基因相比，存在一个或多个apoE4等位基因时AD的调整优势比为10.39（95%CI 1.77 - 61.10；p = 0.010）。与AD患者相比，对照组的平均最小MTL厚度显著更高（p < 0.001）。来自斯里兰卡的关于apoE4、血浆tHcy、MTL厚度和AD的这篇首次报告表明，高血浆tHcy、apoE4等位基因的存在以及MTL萎缩与AD相关。
