Stitt Alan W
Ophthalmic Research Centre, Queen's University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland.
Ann N Y Acad Sci. 2005 Jun;1043:582-97. doi: 10.1196/annals.1338.066.
Diabetes and age-related eye disorders remain leading causes of blindness worldwide. While defined pathogenic mechanisms for many of these diseases remain elusive, there is increasing evidence that products of the Maillard reaction may play an important role in their etiology. Advanced glycation end products (AGEs) form though a range of pathways within Maillard chemistry, and there is evidence to suggest that these adducts accumulate in the intracellular and/or extracellular environment of ocular structures. This review evaluates the ever-growing literature on AGEs in biological systems and draws relevant links to diseases such as diabetic retinopathy, age-related macular degeneration, and cataract formation. It also outlines recent pharmaceutical strategies to inhibit Maillard reaction products and provides links to how these may serve to limit ocular cell dysfunction.
糖尿病和与年龄相关的眼部疾病仍然是全球失明的主要原因。虽然许多这些疾病的明确致病机制仍然难以捉摸，但越来越多的证据表明，美拉德反应产物可能在其病因中起重要作用。晚期糖基化终产物（AGEs）通过美拉德化学中的一系列途径形成，并且有证据表明这些加合物在眼部结构的细胞内和/或细胞外环境中积累。本综述评估了关于生物系统中AGEs的不断增长的文献，并与糖尿病性视网膜病变、年龄相关性黄斑变性和白内障形成等疾病建立了相关联系。它还概述了最近抑制美拉德反应产物的药物策略，并提供了这些策略如何有助于限制眼部细胞功能障碍的相关信息。
