Barr W G, Merchut M P
Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois.
Psychiatr Clin North Am. 1992 Jun;15(2):439-54.
Real or suspected brain involvement occurs in the majority of patients with systemic lupus erythematosus. The clinical manifestations are myriad and are accounted for by diverse pathogenic mechanisms. Purely psychological disturbances and psychiatric syndromes with organic components account for the majority of cases. Metabolic disturbances, drug effects, and infections may masquerade for immune-related brain dysfunction. In the absence of reliable and specific indicators of lupus brain activity, successful management requires the combined skills and clinical judgment of the rheumatologist, neurologist, and psychiatrist.
大多数系统性红斑狼疮患者会出现脑部受累的实际情况或疑似情况。其临床表现多种多样，由多种致病机制导致。大多数病例是纯粹的心理障碍以及伴有器质性成分的精神综合征。代谢紊乱、药物作用和感染可能会伪装成免疫相关的脑功能障碍。在缺乏狼疮脑活动可靠且特异指标的情况下，成功的治疗需要风湿病学家、神经科医生和精神科医生的综合技能与临床判断。
