Shibata Naozumi, Matsui Hidetaka, Takeshita Eiji, Yokota Tomoyuki, Higaki Naoyuki, Murakami Hidehiro, Ikeda Yoshiou, Minami Hisaka, Matsuura Bunzo, Onji Morikazu
The Third Department of Internal Medicine, Ehime University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 2005 Jul;102(7):880-7.
We investigated the alteration of nutritional status in 144 patients who were treated for the first time with endoscopic sclerotherapy or endoscopic variceal ligation during their therapies. The serum levels of albumin, cholinesterase and total cholesterol were compared before and after treatment. The serum level of cholinesterase declined significantly. To investigate the impact of aging on the changes of nutritional status we divided all patients into two groups: (1) under 65 years, and (2) over 65 years. The decline of serum albumin of elderly patients (n=65) was significantly greater than that of younger patients (n=79). A branched-chain amino acid (BCAA)-enriched nutrient mixture for nutritional treatment significantly suppressed the decline of serum albumin in elderly patients. Nutritional treatment with a BCAA-enriched nutrient mixture should be considered during endoscopic therapy for esophageal varices, especially in elderly patients.
我们调查了144例首次接受内镜硬化治疗或内镜下静脉曲张结扎术治疗的患者在治疗期间营养状况的变化。比较了治疗前后血清白蛋白、胆碱酯酶和总胆固醇水平。胆碱酯酶血清水平显著下降。为了研究年龄对营养状况变化的影响,我们将所有患者分为两组:(1)65岁以下,(2)65岁以上。老年患者(n = 65)血清白蛋白的下降明显大于年轻患者(n = 79)。富含支链氨基酸(BCAA)的营养混合物进行营养治疗可显著抑制老年患者血清白蛋白的下降。在内镜治疗食管静脉曲张期间,尤其是老年患者,应考虑使用富含BCAA的营养混合物进行营养治疗。