Massiot Georges, Long Christophe, David Bruno, Serrano Marie-Jeanne, Daubié Florence, Alby Frédéric, Ausseil Frédéric, Knibiehler Martine, Moretti Christian, Hoffmann Jean-Sébastien, Cazaux Christophe, Lavaud Catherine
Joint Service Unit No. 2597, National Center for Scientific Research (CNRS)-Pierre Fabre, Sciences and Technologies Institute of Medicine of Toulouse, 31432 Toulouse, France.
J Nat Prod. 2005 Jul;68(7):979-84. doi: 10.1021/np049676o.
Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl side chains with TFA, water, and acetonitrile. All the compounds were assayed for their ability to inhibit human DNA polymerase beta. The most active compounds, mahureones A (1) and D (5), exhibited IC50 values in the 10 microM range.
