Gusev N B, Bukach O V, Marston S B
Department of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Biochemistry (Mosc). 2005 Jun;70(6):629-37. doi: 10.1007/s10541-005-0162-8.
This review is devoted to critical analysis of data concerning the structure and functions of small heat shock proteins with apparent molecular mass 20 kD (Hsp20). We describe the structure of Hsp20, its phosphorylation by different protein kinases, interaction of Hsp20 with other small heat shock proteins, and chaperone activity of Hsp20. The distribution of Hsp20 in different animal tissues and the factors affecting expression of Hsp20 are also described. Data on the possible involvement of Hsp20 in regulation of platelet aggregation and glucose transport are presented and analyzed. Special attention is paid to literature data describing probable regulatory effect of Hsp20 on contraction of smooth muscle. Two hypotheses postulating direct effect of Hsp20 on actomyosin interaction or its effect on cytoskeleton are compared and analyzed. The most recent data on the effect of Hsp20 on apoptosis and contractile activity of cardiomyocytes are also presented.
本综述致力于对表观分子量为20kD的小热休克蛋白（Hsp20）的结构和功能相关数据进行批判性分析。我们描述了Hsp20的结构、其被不同蛋白激酶磷酸化的情况、Hsp20与其他小热休克蛋白的相互作用以及Hsp20的伴侣活性。还描述了Hsp20在不同动物组织中的分布以及影响Hsp20表达的因素。展示并分析了关于Hsp20可能参与血小板聚集和葡萄糖转运调节的数据。特别关注了描述Hsp20对平滑肌收缩可能具有调节作用的文献数据。比较并分析了两种假设，即Hsp20对肌动球蛋白相互作用的直接影响或其对细胞骨架的影响。还展示了关于Hsp20对心肌细胞凋亡和收缩活性影响的最新数据。
