Feller Scott E, Gawrisch Klaus
Department of Chemistry, Wabash College, Crawfordsville, IN 47933, USA.
Curr Opin Struct Biol. 2005 Aug;15(4):416-22. doi: 10.1016/j.sbi.2005.07.002.
The importance of highly polyunsaturated fatty acids in health and development has been convincingly demonstrated by many studies over the past several decades. The mechanisms by which polyunsaturated lipid species might influence biological function at the molecular level are now attracting considerable attention. The G-protein-coupled receptor rhodopsin and docosahexaenoic acid, the dominant fatty acid in the retinal membrane, provide the best-studied example of protein function being influenced by lipid environment.
在过去几十年中，许多研究令人信服地证明了高度多不饱和脂肪酸在健康和发育中的重要性。多不饱和脂质种类可能在分子水平上影响生物学功能的机制目前正引起相当大的关注。G蛋白偶联受体视紫红质和二十二碳六烯酸（视网膜膜中的主要脂肪酸）为蛋白质功能受脂质环境影响提供了研究最为充分的例子。
