Xu Dashun, Curtis Jason, Feng Zhilan, Minchella Dennis J
Department of Mathematics, Purdue University, West Lafayette, IN 47907, USA.
Bull Math Biol. 2005 Nov;67(6):1207-26. doi: 10.1016/j.bulm.2005.01.007.
The effects of drug treatment of human hosts upon a population of schistosome parasites depend upon a variety of factors. Previous models have shown that multiple strains of drug-resistant parasites are likely to be favored as the treatment rate increases. However, such models have neglected to account for the complex nature of schistosome mating biology. To more accurately account for the biology of these parasites, a simple mating structure is included in a multi-strain schistosome model, with parasites under the influence of drug treatment of their human hosts. Parasites are assumed to pay a cost for drug resistance in terms of reduced reproduction and transmission. The dynamics of the parasite population are described by a system of homogeneous differential equations, and the existence and stability of the exponential solutions for this system are used to infer the impact of drug treatment on the maintenance of schistosome genetic diversity.
药物治疗人类宿主对血吸虫种群的影响取决于多种因素。先前的模型表明，随着治疗率的提高，多种耐药寄生虫菌株可能更具优势。然而，此类模型忽略了血吸虫交配生物学的复杂性。为了更准确地考虑这些寄生虫的生物学特性，在一个多菌株血吸虫模型中纳入了一个简单的交配结构，其中寄生虫受到对其人类宿主进行药物治疗的影响。假定寄生虫在耐药性方面要付出繁殖和传播减少的代价。寄生虫种群的动态由一个齐次微分方程组描述，并且利用该系统指数解的存在性和稳定性来推断药物治疗对血吸虫遗传多样性维持的影响。
