Fogarty Marie P, Kessler Jessica D, Wechsler-Reya Robert J
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
J Neurobiol. 2005 Sep 15;64(4):458-75. doi: 10.1002/neu.20166.
Morphogens play a critical role in most aspects of development, including expansion and patterning of the central nervous system. Activating germline mutations in components of the Hedgehog and Wnt pathways have provided evidence for the important roles morphogens play in the genesis of brain tumors such as cerebellar medulloblastoma. In addition, aberrant expression of transforming growth factor-beta (TGF-beta) superfamily members has been demonstrated to contribute to progression of malignant gliomas. This review summarizes our current knowledge about the roles of morphogens in central nervous system tumorigenesis.
形态发生素在发育的大多数方面都起着关键作用，包括中枢神经系统的扩展和模式形成。刺猬信号通路和Wnt信号通路成分中的种系激活突变，为形态发生素在小脑髓母细胞瘤等脑肿瘤发生中所起的重要作用提供了证据。此外，转化生长因子-β（TGF-β）超家族成员的异常表达已被证明与恶性胶质瘤的进展有关。本综述总结了我们目前关于形态发生素在中枢神经系统肿瘤发生中作用的知识。
