Viswanathan Hema, Anderson Rodney, Thomas Joseph
School of Pharmacy and Pharmacal Sciences, Department of Pharmacy Practice, Purdue University, West Lafayette, IN 47907-2091, USA.
Qual Life Res. 2005 May;14(4):935-44. doi: 10.1007/s11136-004-3507-7.
This study describes health-related quality of life (HRQOL) among low-income HIV adults using an HIV service center, compares participants' scores to US published norms for the general population and persons with chronic conditions, and examines relationships between patient characteristics, nonadherence, and HRQOL.
A cross-sectional survey of individuals on antiretroviral therapy was conducted. The Medical Outcomes Study SF-12 was used to assess HRQOL. Medication nonadherence was assessed using the 9-item Morisky Adherence Scale. Data also were collected on social support, CD4 cell count, and time since diagnosis.
Approximately 84% of the 86 participants were male, 50% were white, and 39% were black. The mean +/- SD Physical component summary (PCS-12) score of 41.0 +/- 12.5 and Mental component summary (MCS-12) score of 41.9 +/- 11.0 were lower than US general population norms (p < 0.001). PCS-12 scores were similar to those of patients with other chronic conditions. Respondents reported lower MCS-12 scores than patients with hypertension and diabetes (p < 0.006). Employment and higher social support had positive associations with PCS-12 scores and nonadherence had a negative association with MCS-12 scores (p < 0.05).
HRQOL in this sample of low-income HIV adults was comparable to other HIV populations. Identifying strategies for increasing social support and medication adherence for economically disadvantaged persons with HIV/ AIDS may improve their HRQOL.
本研究描述了使用艾滋病服务中心的低收入成年艾滋病病毒感染者的健康相关生活质量(HRQOL),将参与者的得分与美国公布的一般人群和慢性病患者的标准进行比较,并研究患者特征、不依从性和健康相关生活质量之间的关系。
对接受抗逆转录病毒治疗的个体进行了横断面调查。使用医学结果研究SF-12来评估健康相关生活质量。使用9项Morisky依从性量表评估药物不依从性。还收集了关于社会支持、CD4细胞计数和诊断后时间的数据。
86名参与者中约84%为男性,50%为白人,39%为黑人。身体成分总结(PCS-12)平均得分±标准差为41.0±12.5,心理成分总结(MCS-12)平均得分±标准差为41.9±11.0,低于美国一般人群标准(p<0.001)。PCS-12得分与其他慢性病患者相似。受访者报告的MCS-12得分低于高血压和糖尿病患者(p<0.006)。就业和更高的社会支持与PCS-12得分呈正相关,不依从性与MCS-12得分呈负相关(p<0.05)。
该低收入成年艾滋病病毒感染者样本中的健康相关生活质量与其他艾滋病病毒感染人群相当。为经济上处于不利地位的艾滋病病毒/艾滋病患者确定增加社会支持和药物依从性的策略可能会改善他们的健康相关生活质量。