Morley J E, Haren M T, Kim M J, Kevorkian R, Perry H M
Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA.
J Endocrinol Invest. 2005;28(3 Suppl):76-80.
Testosterone levels decline over the lifespan. Many symptoms of hypogonadism are similar to age-related changes in older males. A small number of studies have suggested that some of these symptoms may be reversed by testosterone. Among them, one trial has suggested that decline in bioavailable testosterone may be related to the development of functional decline. Testosterone replacement during rehabilitation may improve functional outcomes and plays an important role in the maintenance of sexual related quality of life. The overall improvement in well-being and/or health-related quality of life in older males needs to be determined with large placebo-controlled trials. This is particularly important in view of the substantial placebo effect on aging symptomatology.
睾酮水平在整个生命周期中会下降。性腺功能减退的许多症状与老年男性与年龄相关的变化相似。少数研究表明，其中一些症状可能通过睾酮得到逆转。其中，一项试验表明，生物可利用睾酮的下降可能与功能衰退的发展有关。康复期间进行睾酮替代治疗可能会改善功能结局，并在维持性相关生活质量方面发挥重要作用。老年男性幸福感和/或健康相关生活质量的总体改善需要通过大型安慰剂对照试验来确定。鉴于安慰剂对衰老症状有显著影响，这一点尤为重要。
