Kiss D, Meier R, Gyr K, Wegmann W
Dialysestation, Medizinische Klinik, Kantonsspital, Liestal.
Schweiz Med Wochenschr. 1992 May 30;122(22):854-7.
A 58-year-old female patient admitted to hospital for advanced renal failure had a 40 years' history of Crohn's disease and had undergone ileocecal resection. Nevertheless, chronic diarrhea persisted. Subsequently calcium oxalate stones in the urine were repeatedly observed. Progressive renal failure developed. The investigation of the patient showed severe steatorrhea and pronounced hyperoxaluria, and renal biopsy showed severe chronic interstitial nephritis with calcium oxalate crystals. The skin biopsy revealed severe calcium oxalate vasculitis. The pathophysiology and therapy of secondary hyperoxaluria due to small bowel resection are discussed.
一名因晚期肾衰竭入院的58岁女性患者,有40年克罗恩病病史,已接受回盲部切除术。然而,慢性腹泻仍持续存在。随后反复观察到尿中草酸钙结石。出现了进行性肾衰竭。对该患者的检查显示严重脂肪泻和明显高草酸尿症,肾活检显示严重慢性间质性肾炎伴草酸钙结晶。皮肤活检显示严重草酸钙血管炎。本文讨论了小肠切除术后继发性高草酸尿症的病理生理学及治疗。