Kouyoumdjian Maria, Nagaoka Márcia Regina, Borges Durval Rosa
Department of Biochemistry, Universidade Federal de São Paulo, Rua Botucatu 862 (Ed JL Prado), 04023-900 São Paulo, SP, Brazil.
Peptides. 2005 Aug;26(8):1301-7. doi: 10.1016/j.peptides.2005.03.024. Epub 2005 Apr 26.
The purpose of this brief review is to describe some characteristics of the kallikrein-kinin system (KKS) in the liver. The liver synthesizes kininogens and prekallikrein and the synthesis of both proteins is increased in rats during the acute phase reaction. It is also the main organ to clear tissue as well as plasma kallikrein from the circulation in normal and pathological conditions. Bradykinin (BK), yielded by the kallikrein-kinin system, is a potent arterial hypotensive peptide, but in the liver it induces a portal hypertensive response. The portal hypertensive action of bradykinin is mediated by B2 receptors located on sinusoidal cells of the periportal region and is followed by its hydrolysis by angiotensin-converting enzyme, which is primarily present in the perivenous (centrolobular) region.
本简要综述的目的是描述肝脏中激肽释放酶-激肽系统（KKS）的一些特征。肝脏合成激肽原和前激肽释放酶，在急性期反应期间，大鼠体内这两种蛋白质的合成均增加。在正常和病理条件下，肝脏也是从循环中清除组织激肽释放酶以及血浆激肽释放酶的主要器官。激肽释放酶-激肽系统产生的缓激肽（BK）是一种强效的动脉降压肽，但在肝脏中它会引发门静脉高压反应。缓激肽的门静脉高压作用由位于门静脉周围区域窦状细胞上的B2受体介导，随后被主要存在于静脉周围（小叶中心）区域的血管紧张素转换酶水解。
