Poyurovsky Michael, Michaelovsky Elena, Frisch Amos, Knoll Gabriela, Amir Ilan, Finkel Boris, Buniak Feodor, Hermesh Haggai, Weizman Ronit
Tirat Hacarmel Mental Health Center, Tirat Carmel, Israel.
Neurosci Lett. 2005 Nov 25;389(1):21-4. doi: 10.1016/j.neulet.2005.06.064.
This is the first study of a possible molecular genetic basis for schizophrenia with obsessive-compulsive disorder (OCD). We performed a case-control association study of the catechol-O-methyltransferase (COMT) Val158Met polymorphism in schizophrenia-OCD patients, OCD and healthy controls. One hundred and thirteen schizophrenia-OCD patients, 79 OCD patients and 171 control subjects were genotyped for the Val(158)Met polymorphism in the COMT gene. There was no significant difference in allele and genotype distribution of the COMT gene between schizophrenia-OCD patients and healthy controls. The low-activity Met allele and Met/Met genotype were more frequent in OCD men than in schizophrenia-OCD and control individuals. This difference, however, was not statistically significant following correction for multiple comparisons. These results do not support the hypothesis that the COMT Val158Met gene polymorphism is associated with liability to schizophrenia-OCD.
这是对伴有强迫症（OCD）的精神分裂症可能的分子遗传基础进行的首次研究。我们对精神分裂症-强迫症患者、强迫症患者和健康对照者进行了儿茶酚-O-甲基转移酶（COMT）Val158Met多态性的病例对照关联研究。对113例精神分裂症-强迫症患者、79例强迫症患者和171例对照者进行了COMT基因Val(158)Met多态性的基因分型。精神分裂症-强迫症患者与健康对照者之间COMT基因的等位基因和基因型分布没有显著差异。低活性Met等位基因和Met/Met基因型在强迫症男性中比在精神分裂症-强迫症患者和对照个体中更常见。然而，在进行多重比较校正后，这种差异没有统计学意义。这些结果不支持COMT Val158Met基因多态性与精神分裂症-强迫症易感性相关的假说。
