McClure Kimberlee D, McClure Samuel M, Richter Marlene C, Richter Wolfgang
Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.
Neuroimage. 2005 Oct 1;27(4):817-23. doi: 10.1016/j.neuroimage.2005.05.054.
Numerous parameters such as subject age, region of activation, and stimulus timing are known to affect the BOLD signal following neural activation. Here, we investigated how differences in the rest time between successive long visual stimuli alter the kinetics of the BOLD signal in the visual cortex. We found that the BOLD rise time varies with the inter-stimulus interval. By taking this into account when performing statistical analyses of BOLD data, we show that a roughly 20% increase in statistical power can be achieved. In addition, the dependence of the BOLD signal rise time on the inter-stimulus interval provides insight into the physiology underlying the post-stimulus undershoot.
已知许多参数，如受试者年龄、激活区域和刺激时间，会影响神经激活后的血氧水平依赖（BOLD）信号。在此，我们研究了连续长时间视觉刺激之间的休息时间差异如何改变视觉皮层中BOLD信号的动力学。我们发现BOLD上升时间随刺激间隔而变化。在对BOLD数据进行统计分析时考虑到这一点，我们表明统计功效可提高约20%。此外，BOLD信号上升时间对刺激间隔的依赖性为刺激后负向波的生理机制提供了见解。
