慢性粒单核细胞白血病中发育异常的中性粒细胞的红细胞吞噬作用及随后向急性髓系白血病的转化。

Erythrophagocytosis by dysplastic neutrophils in chronic myelomonocytic leukemia and subsequent transformation to acute myeloid leukemia.

作者信息

Etzell Joan, Lu Chuanyi M, Browne L Walden, Wang Endi

机构信息

Clinical Hematology Laboratory, Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California 94143-0100, USA.

出版信息

Am J Hematol. 2005 Aug;79(4):340-2. doi: 10.1002/ajh.20392.

DOI:10.1002/ajh.20392

PMID:16044446

Abstract

Erythrophagocytosis by neutrophils is a rare phenomenon in myeloid malignancies, and its clinicopathologic significance is not fully understood. We report a unique case of erythrophagocytosis by dysplastic neutrophils in chronic myelomonocytic leukemia (CMML) and subsequent transformation to acute myeloid leukemia (AML). Review of multiple marrow samples, both pretreatment and post-treatment, demonstrated a correlation between percentage of dysplastic neutrophils and degree of erythrophagocytosis. Erythrophagocytosis was observed only in dysplastic forms of neutrophils. Post-transplant marrows with engraftment of donor cells showed no neutrophilic dysplasia or erythrophagocytosis. Possible mechanisms of neutrophilic erythrophagocytosis in myeloid malignancies are discussed.

摘要

中性粒细胞吞噬红细胞在髓系恶性肿瘤中是一种罕见现象，其临床病理意义尚未完全明确。我们报告了1例慢性粒单核细胞白血病（CMML）中发育异常的中性粒细胞吞噬红细胞并随后转化为急性髓系白血病（AML）的独特病例。对治疗前和治疗后的多份骨髓样本进行回顾，发现发育异常的中性粒细胞百分比与红细胞吞噬程度之间存在相关性。仅在发育异常的中性粒细胞中观察到红细胞吞噬现象。供体细胞植入后的移植后骨髓未显示中性粒细胞发育异常或红细胞吞噬现象。本文讨论了髓系恶性肿瘤中中性粒细胞吞噬红细胞的可能机制。