Cherrier M M
Department of Psychiatry and Behavioral Sciences, University of Washington, School of Medicine and Veterans Administration Puget Sound Health Care System, Seattle 98108, USA.
J Endocrinol Invest. 2005;28(3 Suppl):65-75.
Decrements in cognitive functioning are a common complaint among men with late-onset hypogonadism (LOH). This article reviews the neurobiologic connection between gonadal steroids and cognitive functions, developmental effects and activational effects throughout the lifespan. Studies of hormone replacement therapy in older men are reviewed as well as epidemiological studies of endogenous hormones and cognition. While many studies of Androgen Replacement Therapy (ART) in older men suggest a potential beneficial effect on cognition, most studies to date have been small and need further replication with larger sample sizes.
认知功能减退是迟发性性腺功能减退（LOH）男性的常见主诉。本文综述了性腺类固醇与认知功能之间的神经生物学联系，以及一生中的发育影响和激活作用。还综述了老年男性激素替代疗法的研究以及内源性激素与认知的流行病学研究。虽然许多关于老年男性雄激素替代疗法（ART）的研究表明对认知有潜在的有益影响，但迄今为止大多数研究规模较小，需要用更大的样本量进行进一步验证。
