Zhang Bo, Gu Yi, Li Yuanyuan, Feng Xingliang
Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
Department of Urology, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
PLoS One. 2025 Jun 9;20(6):e0323900. doi: 10.1371/journal.pone.0323900. eCollection 2025.
Testosterone levels are closely associated with visceral obesity, insulin resistance, and lipid metabolism. The objective of this study was to investigate the associations among eight indicators related to visceral obesity, insulin resistance, lipid metabolism, and testosterone levels.
The data were obtained from a cross-sectional survey based on National Health and Nutrition Examination Survey (NHANES) 2013-2016. Logistic and linear regression were employed to assess the associations between these inicators and testosterone levels. Simultaneously, the receiver operating characteristic (ROC) curve was utilized to evaluate their predictive capacity for testosterone deficiency (TD).
Data from a collective of 1514 individuals selected from NHANES were analyzed. After adjusting all potential confounders, a tight association was identified between these eight indexes and TD. The ROC curve analysis showed that the triglyceride-glucose waist-to-height ratio (TyG-WHtR)is the best predictor of testosterone deficiency (AUC: 0.7760, 95%CI: 0.7460-0.8060), with a cut-off value of 5.375. Further analyses indicated that participants with higher TyG-WHtR index exhibitrd a lower total testosterone level(β: -79.36,95%CI: -105.90, -52.82). Additionally, males in TyG-WHtR index tertile 3 had a higher risk of TD (OR: 6.61, 95%CI: 2.90,15.07), and lower total testosterone levels (β: -121.9, 95%CI: -186.82, -56.98). All the results remained stable in the subgroup analyses stratified by diabetes and hypertension.
We found that these indexses are tightly associated with testosterone levels in U.S. adult men. Moreover, the TyG-WHtR index demonstrates the most effective predictive performance in the population. However, more well-designed studies are still needed to validate their association.
睾酮水平与内脏肥胖、胰岛素抵抗及脂质代谢密切相关。本研究的目的是调查与内脏肥胖、胰岛素抵抗、脂质代谢及睾酮水平相关的八项指标之间的关联。
数据来自基于2013 - 2016年美国国家健康与营养检查调查（NHANES）的横断面调查。采用逻辑回归和线性回归来评估这些指标与睾酮水平之间的关联。同时，利用受试者工作特征（ROC）曲线来评估它们对睾酮缺乏（TD）的预测能力。
对从NHANES中选取的1514名个体的数据进行了分析。在调整所有潜在混杂因素后，发现这八项指标与TD之间存在紧密关联。ROC曲线分析表明，甘油三酯 - 血糖腰高比（TyG - WHtR）是睾酮缺乏的最佳预测指标（AUC：0.7760，95%CI：0.7460 - 0.8060），截断值为5.375。进一步分析表明，TyG - WHtR指数较高的参与者总睾酮水平较低（β： - 79.36，95%CI： - 105.90， - 52.82）。此外，TyG - WHtR指数处于第三三分位数的男性患TD的风险更高（OR：6.61，95%CI：2.90，15.07），且总睾酮水平较低（β： - 121.9，95%CI： - 186.82， - 56.98）。在按糖尿病和高血压分层的亚组分析中，所有结果均保持稳定。
我们发现这些指标与美国成年男性的睾酮水平紧密相关。此外，TyG - WHtR指数在人群中表现出最有效的预测性能。然而，仍需要更多设计良好的研究来验证它们之间的关联。
