Siracusano A, Buttari B, Delunardo F, Profumo E, Margutti P, Ortona E, Riganò R, Teggi A
Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Roma, Italy.
Parassitologia. 2004 Dec;46(4):401-3.
This study discusses the immunodiagnosis of cystic echinococcosis (ce, caused by Echinococcus granulosus). The detection by immunoblotting of antibodies specific for the 8 kDa subunit of antigen B and in particular the IgG4 subclass expression, seems the most promising serodiagnostic tool. Despite the development of molecular methods, nowadays there is no standard, highly sensitive, and specific test available for antibody detection in CE. Furthermore, because serological tests can give only a limited support to clinical findings there is a clear need for new advances in immunodiagnosis of E. granulosus infection.
本研究探讨了囊性棘球蚴病（由细粒棘球绦虫引起的ce）的免疫诊断。通过免疫印迹法检测抗原B 8 kDa亚基特异性抗体，尤其是IgG4亚类表达，似乎是最有前景的血清学诊断工具。尽管分子方法有所发展，但目前尚无用于检测CE抗体的标准、高灵敏度和特异性的检测方法。此外，由于血清学检测对临床诊断的支持有限，因此在细粒棘球绦虫感染的免疫诊断方面显然需要新的进展。
