Sumimoto R, Dohi K, Urushihara T, Jamieson N V, Ito H, Sumimoto K, Fukuda Y
Second Department of Surgery, Hiroshima University, School of Medicine, Japan.
Transplantation. 1992 Jun;53(6):1206-10. doi: 10.1097/00007890-199206000-00007.
Fifty-five rat pancreas transplants, 18 rat heart transplants, and 41 rat liver transplants were performed using standard UW solution, the new HL solution (HL-I), or a modified HL solution (HL-II). Storage times of 18 hr were used in the heart preservation experiments, 24 hr in the liver preservation experiments, and 48 or 72 hr in the pancreas preservation experiments. HL-I solution was superior to both HL-II and UW solution for heart preservation (1-week graft survival rates of 100% [7/7], 0% [0/5], and 50% [3/6], respectively). HL-I and HL-II were superior to UW for 24 hr liver preservation (1-week graft survival rates of 78% [11/14], 80% [8/10], and 29% [5/17], respectively). In contrast, HL-II was superior to both HL-I and UW solutions for pancreas preservation following both 48-hr preservation and 72-hr preservation. Satisfactory graft function was achieved in 100% (7/7), 40% (6/15), and 44.4% (4/9) of pancreases transplanted after 48 hr using HL-II, HL-I, and UW solutions, respectively, and in 50% (4/8), 0% (0/8), and 0% (0/8) following 72-hr preservation. Histidine- and lactobionate-containing solutions thus represent a further improvement in organ preservation by simple cold storage.
使用标准UW溶液、新型HL溶液（HL-I）或改良HL溶液（HL-II）进行了55例大鼠胰腺移植、18例大鼠心脏移植和41例大鼠肝脏移植。心脏保存实验采用18小时的保存时间，肝脏保存实验采用24小时，胰腺保存实验采用48或72小时。在心脏保存方面，HL-I溶液优于HL-II溶液和UW溶液（1周移植存活率分别为100%[7/7]、0%[0/5]和50%[3/6]）。在24小时肝脏保存方面，HL-I和HL-II优于UW溶液（1周移植存活率分别为78%[11/14]、80%[8/10]和29%[5/17]）。相比之下，在48小时和72小时保存后，HL-II在胰腺保存方面优于HL-I溶液和UW溶液。使用HL-II、HL-I和UW溶液在48小时后移植的胰腺中，分别有100%（7/7）、40%（6/15）和44.4%（4/9）实现了满意的移植功能，在72小时保存后分别为50%（4/8）、0%（0/8）和0%（0/8）。因此，含组氨酸和乳糖酸盐的溶液通过简单冷藏在器官保存方面代表了进一步的改进。
