Laurencin Cato T, Freeman Joseph W
Department of Orthopaedic Surgery, University of Virginia, Charlottesville, VA 22903, USA.
Biomaterials. 2005 Dec;26(36):7530-6. doi: 10.1016/j.biomaterials.2005.05.073.
The anterior cruciate ligament (ACL) is important for knee stabilization. Unfortunately, it is also the most commonly injured intra-articular ligament. Due to poor vascularization, the ACL has inferior healing capability and is usually replaced after significant damage has occurred. Currently available replacements have a host of limitations, this has prompted the search for tissue-engineered solutions for ACL repair. Presently investigated scaffolds range from twisted fiber architectures composed of silk fibers to complex three-dimensional braided structures composed of poly (L-lactic acid) fibers. The purpose of these tissue-engineered constructs is to apply approaches such as the use of porous scaffolds, use of cells, and the application of growth factors to promote ligament tissue regeneration while providing mechanical properties similar to natural ligament.
前交叉韧带（ACL）对膝关节稳定至关重要。不幸的是，它也是最常受伤的关节内韧带。由于血管化程度差，ACL的愈合能力较差，通常在发生严重损伤后进行置换。目前可用的替代品有许多局限性，这促使人们寻找用于ACL修复的组织工程解决方案。目前研究的支架范围从由丝纤维组成的扭曲纤维结构到由聚（L-乳酸）纤维组成的复杂三维编织结构。这些组织工程构建体的目的是应用诸如使用多孔支架、使用细胞和应用生长因子等方法来促进韧带组织再生，同时提供与天然韧带相似的机械性能。
