仿生组织工程化前交叉韧带置换物
Biomimetic tissue-engineered anterior cruciate ligament replacement.
作者信息
Cooper James A, Sahota Janmeet S, Gorum W Jay, Carter Janell, Doty Stephen B, Laurencin Cato T
机构信息
School of Biomedical, Engineering, Science, and Health Systems and Center for Advanced Biomaterials and Tissue Engineering, 3141 Chestnut Street, Drexel University, Philadelphia, PA 19104, USA.
出版信息
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3049-54. doi: 10.1073/pnas.0608837104. Epub 2007 Feb 20.
Abstract
There are >200,000 anterior cruciate ligament (ACL) ruptures each year in the United States, and, due to the poor healing properties of the ACL, surgical reconstruction with autograft or allograft tissue is the current treatment of these injuries. To regenerate the ACL, the ideal matrix should be biodegradable, porous, and exhibit sufficient mechanical strength to allow formation of neoligament tissue. Researchers have developed ACL scaffolds with collagen fibers, silk, biodegradable polymers, and composites with limited success. Our group has developed a biomimetic ligament replacement by using 3D braiding technology. In this preliminary in vivo rabbit model study for ACL reconstruction, the histological and mechanical evaluation demonstrated excellent healing and regeneration with our cell-seeded, tissue-engineered ligament replacement.
摘要
在美国，每年有超过20万例前交叉韧带（ACL）断裂，由于ACL的愈合特性较差，目前对这些损伤的治疗方法是使用自体移植物或同种异体移植物进行手术重建。为了再生ACL，理想的基质应具有生物可降解性、多孔性，并表现出足够的机械强度以允许新韧带组织的形成。研究人员已经开发了含有胶原纤维、丝绸、生物可降解聚合物和复合材料的ACL支架，但取得的成功有限。我们的团队利用3D编织技术开发了一种仿生韧带替代物。在这项用于ACL重建的兔体内初步模型研究中，组织学和力学评估表明，我们的细胞接种组织工程韧带替代物具有出色的愈合和再生效果。
相似文献
1
Biomimetic tissue-engineered anterior cruciate ligament replacement.仿生组织工程化前交叉韧带置换物
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3049-54. doi: 10.1073/pnas.0608837104. Epub 2007 Feb 20.
2
Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies.使用编织型可生物降解支架进行前交叉韧带再生：体外优化研究
Biomaterials. 2005 Aug;26(23):4805-16. doi: 10.1016/j.biomaterials.2004.11.050. Epub 2005 Jan 13.
3
Ligament tissue engineering: an evolutionary materials science approach.韧带组织工程：一种渐进性的材料科学方法。
Biomaterials. 2005 Dec;26(36):7530-6. doi: 10.1016/j.biomaterials.2005.05.073.
4
Ectopic tissue engineered ligament with silk collagen scaffold for ACL regeneration: A preliminary study.用于前交叉韧带再生的丝胶原支架异位组织工程韧带：一项初步研究。
Acta Biomater. 2017 Apr 15;53:307-317. doi: 10.1016/j.actbio.2017.02.027. Epub 2017 Feb 16.
5
Anterior Cruciate Ligament: Structure, Injuries and Regenerative Treatments.前交叉韧带：结构、损伤与再生治疗
Adv Exp Med Biol. 2015;881:161-86. doi: 10.1007/978-3-319-22345-2_10.
6
The effects of bone marrow-derived mesenchymal stem cells and fascia wrap application to anterior cruciate ligament tissue engineering.骨髓间充质干细胞及筋膜包裹应用于前交叉韧带组织工程的效果
Cell Transplant. 2005;14(10):763-73. doi: 10.3727/000000005783982486.
7
A Novel Silk Fiber-Based Scaffold for Regeneration of the Anterior Cruciate Ligament: Histological Results From a Study in Sheep.一种用于前交叉韧带再生的新型丝纤维基支架：绵羊研究的组织学结果
Am J Sports Med. 2016 Jun;44(6):1547-57. doi: 10.1177/0363546516631954. Epub 2016 Mar 8.
8
Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation.用于韧带替代的纤维基组织工程支架：设计考量与体外评估
Biomaterials. 2005 May;26(13):1523-32. doi: 10.1016/j.biomaterials.2004.05.014.
9
Evaluation of polycaprolactone scaffold with basic fibroblast growth factor and fibroblasts in an athymic rat model for anterior cruciate ligament reconstruction.在无胸腺大鼠模型中，评估聚己内酯支架联合碱性成纤维细胞生长因子及成纤维细胞用于前交叉韧带重建的效果。
Tissue Eng Part A. 2015 Jun;21(11-12):1859-68. doi: 10.1089/ten.TEA.2014.0366. Epub 2015 Apr 7.
10
Tissue engineering of the anterior cruciate ligament using a braid-twist scaffold design.使用编织-扭转支架设计的前交叉韧带组织工程
J Biomech. 2007;40(9):2029-36. doi: 10.1016/j.jbiomech.2006.09.025. Epub 2006 Nov 13.
引用本文的文献
1
Classes of Stem Cells: From Biology to Engineering.干细胞类别：从生物学到工程学
Regen Eng Transl Med. 2024 Sep;10(3):309-322. doi: 10.1007/s40883-023-00317-x. Epub 2023 Sep 18.
2
Animal Models of Osteoarthritis: Updated Models and Outcome Measures 2016-2023.骨关节炎动物模型：2016 - 2023年更新的模型与结果测量
Regen Eng Transl Med. 2024 Jun;10(2):127-146. doi: 10.1007/s40883-023-00309-x. Epub 2023 Jun 27.
3
Hyaluronic acid-British anti-Lewisite as a safer chelation therapy for the treatment of arthroplasty-related metallosis.透明质酸-英国抗路易士剂作为一种更安全的螯合疗法，用于治疗关节置换术后相关金属中毒。
Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2309156120. doi: 10.1073/pnas.2309156120. Epub 2023 Oct 30.
4
Could an Anterior Cruciate Ligament Be Tissue-Engineered from Silk?能否从丝中构建前交叉韧带？
Cells. 2023 Sep 25;12(19):2350. doi: 10.3390/cells12192350.
5
Mimicking the Graded Wavy Structure of the Anterior Cruciate Ligament.模拟前交叉韧带的分级波浪结构。
Adv Healthc Mater. 2023 Jul;12(17):e2203023. doi: 10.1002/adhm.202203023. Epub 2023 Apr 2.
6
Osteochondral regenerative engineering: challenges, state-of-the-art and translational perspectives.骨软骨再生工程：挑战、现状与转化前景
Regen Biomater. 2022 Dec 26;10:rbac109. doi: 10.1093/rb/rbac109. eCollection 2023.
7
Ligament Regenerative Engineering: Braiding Scalable and Tunable Bioengineered Ligaments Using a Bench-Top Braiding Machine.韧带再生工程：使用台式编织机编织可扩展且可调谐的生物工程韧带
Regen Eng Transl Med. 2021 Dec;7(4):524-532. doi: 10.1007/s40883-020-00178-8. Epub 2020 Oct 6.
8
Enhancing the Surface Properties of a Bioengineered Anterior Cruciate Ligament Matrix for Use with Point-of-Care Stem Cell Therapy.增强生物工程化前交叉韧带基质的表面特性以用于即时护理干细胞治疗。
Engineering (Beijing). 2021 Feb;7(2):153-161. Epub 2020 May 7.
9
Fibrous Systems as Potential Solutions for Tendon and Ligament Repair, Healing, and Regeneration.纤维系统作为肌腱和韧带修复、愈合及再生的潜在解决方案。
Adv Healthc Mater. 2021 Apr;10(7):e2001305. doi: 10.1002/adhm.202001305. Epub 2021 Feb 12.
10
Bioinspired Scaffold Designs for Regenerating Musculoskeletal Tissue Interfaces.用于再生肌肉骨骼组织界面的仿生支架设计
Regen Eng Transl Med. 2020 Dec;6(4):451-483. doi: 10.1007/s40883-019-00132-3. Epub 2019 Dec 17.
本文引用的文献
1
Evaluation of the anterior cruciate ligament, medial collateral ligament, achilles tendon and patellar tendon as cell sources for tissue-engineered ligament.评估前交叉韧带、内侧副韧带、跟腱和髌腱作为组织工程韧带细胞来源的情况。
Biomaterials. 2006 May;27(13):2747-54. doi: 10.1016/j.biomaterials.2005.12.013. Epub 2006 Jan 18.
2
Anterior cruciate ligament regeneration using braided biodegradable scaffolds: in vitro optimization studies.使用编织型可生物降解支架进行前交叉韧带再生：体外优化研究
Biomaterials. 2005 Aug;26(23):4805-16. doi: 10.1016/j.biomaterials.2004.11.050. Epub 2005 Jan 13.
3
Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation.用于韧带替代的纤维基组织工程支架：设计考量与体外评估
Biomaterials. 2005 May;26(13):1523-32. doi: 10.1016/j.biomaterials.2004.05.014.
4
Silk matrix for tissue engineered anterior cruciate ligaments.用于组织工程化前交叉韧带的丝素基质
Biomaterials. 2002 Oct;23(20):4131-41. doi: 10.1016/s0142-9612(02)00156-4.
5
Preliminary comparison of the rupture of human and rabbit anterior cruciate ligaments.人体与兔前交叉韧带断裂的初步比较
Clin Biomech (Bristol). 2001 Dec;16(10):913-7. doi: 10.1016/s0268-0033(01)00063-8.
6
Tissue engineering: orthopedic applications.组织工程学：骨科应用
Annu Rev Biomed Eng. 1999;1:19-46. doi: 10.1146/annurev.bioeng.1.1.19.
7
Biomechanical and histological changes in the patellar tendon after in situ freezing An experimental study in rabbits.原位冷冻后髌腱的生物力学和组织学变化：一项在兔身上的实验研究
Clin Biomech (Bristol). 1996 Jun;11(4):207-213. doi: 10.1016/0268-0033(95)00075-5.
8
Analysis of retrieved polymer fiber based replacements for the ACL.对检索到的基于聚合物纤维的前交叉韧带替代物的分析。
Biomaterials. 2000 Dec;21(23):2461-74. doi: 10.1016/s0142-9612(00)00114-9.
9
Biomechanics of knee ligaments.膝关节韧带生物力学
Am J Sports Med. 1999 Jul-Aug;27(4):533-43. doi: 10.1177/03635465990270042301.
10
The mechanical properties of skeletally mature rabbit anterior cruciate ligament and patellar tendon over a range of strain rates.在一系列应变率下骨骼成熟兔前交叉韧带和髌腱的力学性能。
J Orthop Res. 1993 Jan;11(1):58-67. doi: 10.1002/jor.1100110108.
Zotero 插件