Cooper James A, Sahota Janmeet S, Gorum W Jay, Carter Janell, Doty Stephen B, Laurencin Cato T
School of Biomedical, Engineering, Science, and Health Systems and Center for Advanced Biomaterials and Tissue Engineering, 3141 Chestnut Street, Drexel University, Philadelphia, PA 19104, USA.
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3049-54. doi: 10.1073/pnas.0608837104. Epub 2007 Feb 20.
There are >200,000 anterior cruciate ligament (ACL) ruptures each year in the United States, and, due to the poor healing properties of the ACL, surgical reconstruction with autograft or allograft tissue is the current treatment of these injuries. To regenerate the ACL, the ideal matrix should be biodegradable, porous, and exhibit sufficient mechanical strength to allow formation of neoligament tissue. Researchers have developed ACL scaffolds with collagen fibers, silk, biodegradable polymers, and composites with limited success. Our group has developed a biomimetic ligament replacement by using 3D braiding technology. In this preliminary in vivo rabbit model study for ACL reconstruction, the histological and mechanical evaluation demonstrated excellent healing and regeneration with our cell-seeded, tissue-engineered ligament replacement.
在美国，每年有超过20万例前交叉韧带（ACL）断裂，由于ACL的愈合特性较差，目前对这些损伤的治疗方法是使用自体移植物或同种异体移植物进行手术重建。为了再生ACL，理想的基质应具有生物可降解性、多孔性，并表现出足够的机械强度以允许新韧带组织的形成。研究人员已经开发了含有胶原纤维、丝绸、生物可降解聚合物和复合材料的ACL支架，但取得的成功有限。我们的团队利用3D编织技术开发了一种仿生韧带替代物。在这项用于ACL重建的兔体内初步模型研究中，组织学和力学评估表明，我们的细胞接种组织工程韧带替代物具有出色的愈合和再生效果。
