Bielsky Isadora F, Hu Shuang-Bao, Young Larry J
Department of Psychiatry, Emory University, Atlanta, GA 30329, USA.
Behav Brain Res. 2005 Oct 14;164(1):132-6. doi: 10.1016/j.bbr.2005.06.005.
Previous findings with an AVP V1a receptor knockout mouse (V1aRKO) demonstrate a significant role for this receptor in anxiety-like behavior in males. Here we report the lack of anxiety-like effects of the null mutation in female mice. V1aRKO females performed normally on all tests for anxiety-like behavior. This sex difference may be due to the sexual dimorphism in the extra-hypothalamic vasopressin system, with males having significantly more vasopressin fibers in this system.
先前对血管加压素V1a受体基因敲除小鼠（V1aRKO）的研究结果表明，该受体在雄性小鼠的焦虑样行为中发挥着重要作用。在此，我们报告基因敲除突变在雌性小鼠中未产生焦虑样效应。V1aRKO雌性小鼠在所有焦虑样行为测试中表现正常。这种性别差异可能归因于下丘脑外血管加压素系统的性二态性，该系统中雄性小鼠的血管加压素纤维显著更多。
