Yuceturk Tolga Enver, Yucel Ahmet Eftal, Yuceturk Handan, Kart-Koseoglu Hamide, Unuvar Ruhan, Ozdemir Fatma Nurhan, Akcaly Zafer
Department of Rheumatology, Baskent University, Ankara, Turkey.
Nephrol Dial Transplant. 2005 Nov;20(11):2485-8. doi: 10.1093/ndt/gfi028. Epub 2005 Jul 26.
Our aim was to determine the prevalence of fibromyalgia syndrome (FS) in chronic haemodialysis (HD) patients and to identify possible links between FS and various clinical and laboratory parameters.
We studied 122 chronic HD patients and 89 healthy age- and sex-matched controls, classified according to the American College of Rheumatology (ACR) classification criteria for FS. Age, sex, causes of renal failure, length of time on dialysis and marital status were recorded, and questions were asked about symptoms related to FS. All subjects completed the Fibromyalgia Impact Questionnaire (FIQ). Laboratory data obtained in the preceding 6 months were re-evaluated.
Nine (7.4%) of the 122 HD patients and four of the 89 control subjects (4.5%) fulfilled the ACR criteria for definite FS (P = 0.56). The mean ages of the subjects who had definite FS and those who did not were similar. Most of the subjects diagnosed with definite FS were female (11 out of 13). The HD patients had higher FIQ scores than the controls, regardless of FS diagnosis. Among the HD patients, those with definite FS had a significantly higher mean FIQ score than all the other HD patients combined. In the all HD patients group, fatigue, irritable bowel syndrome and personal histories of depression were correlated with FS, whereas duration of HD, aetiology of renal failure, laboratory parameters and hepatitis B or C virus infection were not.
The prevalence of FS appeared to be similar in chronic HD patients and the general population; also, FS-related symptoms appear to be similar in HD patients and the general population who have FS. No laboratory parameter was correlated with frequency of FS.
我们的目的是确定慢性血液透析（HD）患者中纤维肌痛综合征（FS）的患病率，并确定FS与各种临床和实验室参数之间可能存在的联系。
我们研究了122例慢性HD患者和89例年龄和性别匹配的健康对照者，根据美国风湿病学会（ACR）的FS分类标准进行分类。记录年龄、性别、肾衰竭原因、透析时间和婚姻状况，并询问与FS相关的症状。所有受试者均完成了纤维肌痛影响问卷（FIQ）。对前6个月获得的实验室数据进行重新评估。
122例HD患者中有9例（7.4%），89例对照者中有4例（4.5%）符合ACR明确FS的标准（P = 0.56）。患有明确FS的受试者和未患明确FS的受试者的平均年龄相似。大多数被诊断为明确FS的受试者为女性（13例中有11例）。无论是否诊断为FS，HD患者的FIQ评分均高于对照组。在HD患者中，患有明确FS的患者的平均FIQ评分明显高于所有其他HD患者的总和。在所有HD患者组中，疲劳、肠易激综合征和抑郁症个人史与FS相关，而HD持续时间、肾衰竭病因、实验室参数以及乙型或丙型肝炎病毒感染与FS无关。
慢性HD患者中FS的患病率似乎与普通人群相似；此外，HD患者和患有FS的普通人群中与FS相关的症状似乎也相似。没有实验室参数与FS的发生频率相关。
