Sumpter John P, Johnson Andrew C
Institute for the Environment, Brunel University, Uxbridge, Middlesex UB8 3PH, UK.
Environ Sci Technol. 2005 Jun 15;39(12):4321-32. doi: 10.1021/es048504a.
In the past 10 years, many thousands of research papers covering the many different aspects of endocrine disruption in the environment have been published. What has been learned from all this research? We have tried to reduce this very large volume of research into a relatively small number of "lessons". Hence, this paper is not a typical review, but instead it summarizes our personal opinions on what we consider are the major messages to have come from all this research. We realize that what has been a lesson to us may have been obvious from the outset to someone more knowledgeable on that particular aspect of the burgeoning field of endocrine disruption. In addition, it is inevitable that others will consider that we have "missed" some lessons that they would have expected to find included in our list. If so, we encourage them to submit them as responses to our paper. Our own lessons range widely, from the design and interpretation of data from fieldwork studies, through some key messages to come out of the very many laboratory studies that have been conducted, to issues around the sources and fates in the environment of endocrine-disrupting chemicals, and finally to the key role of sewage treatment in controlling the concentrations of these chemicals in the aquatic environment. Having (hopefully) learned our lessons, we have then applied them to the difficult issue of how best to approach future concerns about the potential impacts of other new and emerging contaminants (e.g., pharmaceuticals) on wildlife.
在过去十年间，已经发表了成千上万篇涵盖环境内分泌干扰诸多不同方面的研究论文。从所有这些研究中学到了什么呢？我们试图将这大量的研究归纳为相对较少的一些“经验教训”。因此，本文并非一篇典型的综述，而是总结了我们对于我们认为是所有这些研究得出的主要信息的个人观点。我们意识到，对我们来说是一条经验教训的内容，对于在新兴的内分泌干扰领域中该特定方面更有见识的人来说，可能从一开始就很明显。此外，不可避免的是，其他人会认为我们“遗漏”了一些他们原本期望在我们的列表中看到的经验教训。如果是这样，我们鼓励他们作为对我们论文的回应提交这些内容。我们自己的经验教训范围广泛，从实地研究数据的设计与解读，到众多已开展的实验室研究得出的一些关键信息，再到环境中内分泌干扰化学物质的来源与归宿问题，最后到污水处理在控制这些化学物质在水生环境中的浓度方面的关键作用。在（希望）吸取了我们的经验教训之后，我们接着将它们应用于如何最好地应对未来对其他新型和新兴污染物（例如药品）对野生动物潜在影响的担忧这一难题。
