Rajwal S R, Davison S M, Stringer M D, Kinsey S E, McClean P
Children's Liver and G.I. Unit, St James's University Hospital, Leeds, UK.
Pediatr Transplant. 2005 Aug;9(4):537-40. doi: 10.1111/j.1399-3046.2005.00321.x.
This report describes a teenager who developed aplastic anemia (AA) because of non-A-E acute liver failure (ALF) requiring orthotopic liver transplantation (OLT). His AA did not recover spontaneously and he required treatment with ATG 9 months post-OLT. Bone marrow recovery occurred 4 months after immunotherapy and coincided with further intensification of immunusuppression required to treat early chronic rejection of the liver graft. Three years post-OLT he remains well with good bone marrow and liver function. Intensification of immunosuppression can lead to successful resolution of AA associated with non-A-E ALF.
本报告描述了一名青少年，他因非甲非戊型急性肝衰竭（ALF）发展为再生障碍性贫血（AA），需要进行原位肝移植（OLT）。他的再生障碍性贫血没有自发恢复，在肝移植术后9个月需要接受抗胸腺细胞球蛋白（ATG）治疗。免疫治疗4个月后骨髓恢复，这与治疗肝移植早期慢性排斥反应所需的免疫抑制进一步强化同时发生。肝移植术后三年，他情况良好，骨髓和肝功能正常。强化免疫抑制可成功解决与非甲非戊型急性肝衰竭相关的再生障碍性贫血。
