Franklin T B, Krueger-Naug A M, Clarke D B, Arrigo A-P, Currie R W
Laboratory of Molecular Neurobiology, Department of Anatomy and Neurobiology, Dalhousie University, Halifax, NS, Canada.
Int J Hyperthermia. 2005 Aug;21(5):379-92. doi: 10.1080/02656730500069955.
Heat shock proteins (Hsps) are highly conserved and under physiological conditions act as molecular chaperones and/or have anti-apoptotic activities. Expression in the brain of two heat shock proteins, the70 kDa Hsp (Hsp70) and the 27 kDa Hsp (Hsp27), is notable because both proteins are highly inducible in glial cells and neurons following a wide range of noxious stimuli including ischemia, epileptic seizure and hyperthermia. In the central nervous system, constitutive expression of Hsp27 is limited to many (but not all) sensory and motor neurons of the brain stem and spinal cord, while there is little or no constitutive expression of Hsp70. However, inducible expression of both Hsp70 and Hsp27 is present in many areas of the brain and retina and is associated with cellular resistance to a variety of insults. The potential for manipulating the expression levels of Hsps for therapeutic advantage in neurodegenerative diseases such as Alzheimer's disease, stroke and glaucoma will be explored.
热休克蛋白（Hsps）高度保守，在生理条件下作为分子伴侣发挥作用和/或具有抗凋亡活性。两种热休克蛋白，即70 kDa热休克蛋白（Hsp70）和27 kDa热休克蛋白（Hsp27）在脑中的表达值得关注，因为在包括缺血、癫痫发作和高热在内的多种有害刺激后，这两种蛋白在胶质细胞和神经元中都具有高度诱导性。在中枢神经系统中，Hsp27的组成型表达仅限于脑干和脊髓的许多（但不是全部）感觉和运动神经元，而Hsp70几乎没有组成型表达。然而，Hsp70和Hsp27的诱导性表达存在于脑和视网膜的许多区域，并与细胞对各种损伤的抗性相关。将探索通过操纵热休克蛋白的表达水平来治疗诸如阿尔茨海默病、中风和青光眼等神经退行性疾病的可能性。
