School of Bioscience and Technology, Weifang Medical University, Weifang, Shandong, China.
School of Biomedical Engineering and Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Aging Dis. 2024 May 7;15(3):1227-1254. doi: 10.14336/AD.2023.0823-1.
Stroke is a leading cause of death and disability in the world. Astrocytes are special glial cells within the central nervous system and play important roles in mediating neuroprotection and repair processes during stroke. Extracellular vesicles (EVs) are lipid bilayer particles released from cells that facilitate intercellular communication in stroke by delivering proteins, lipids, and RNA to target cells. Recently, accumulating evidence suggested that astrocyte-derived EVs (ADEVs) are actively involved in mediating numerous biological processes including neuroprotection and neurorepair in stroke and they are realized as an excellent therapeutic approach for treating stroke. In this review we systematically summarize the up-to-date research on ADEVs in stroke, and prospects for its potential as a novel therapeutic target for stroke. We also provide an overview of the effects and functions of ADEVs on stroke recovery, which may lead to developing clinically relevant therapies for stroke.
中风是世界上主要的死亡和残疾原因。星形胶质细胞是中枢神经系统中的特殊神经胶质细胞，在中风期间介导神经保护和修复过程中发挥重要作用。细胞外囊泡 (EVs) 是从细胞释放的脂质双层颗粒，通过将蛋白质、脂质和 RNA 递送至靶细胞，促进中风中的细胞间通讯。最近，越来越多的证据表明，星形胶质细胞衍生的 EVs (ADEVs) 积极参与介导中风中的许多生物学过程，包括神经保护和神经修复，并且它们被认为是治疗中风的一种有前途的治疗方法。在这篇综述中，我们系统地总结了关于中风中 ADEVs 的最新研究，并展望了其作为中风新型治疗靶点的潜力。我们还概述了 ADEVs 对中风恢复的影响和功能，这可能为中风的临床相关治疗方法的发展提供思路。
