近平滑念珠菌的卡泊芬净药敏试验：不同方法与最低杀菌浓度的相关性
Caspofungin susceptibility testing of Candida inconspicua: correlation of different methods with the minimal fungicidal concentration.
作者信息
Majoros L, Kardos G, Szabó B, Sipiczki M
机构信息
Department of Medical Microbiology, University of Debrecen, 4032 Debrecen, Nagyerdei krt. 98, Hungary.
出版信息
Antimicrob Agents Chemother. 2005 Aug;49(8):3486-8. doi: 10.1128/AAC.49.8.3486-3488.2005.
Abstract
Minimal inhibitory and minimal fungicidal concentrations of caspofungin were determined for 48 Candida inconspicua isolates. By using CLSI (formerly NCCLS) methodology with the partial inhibition endpoint criterion, caspofungin exhibited a good fungicidal effect against C. inconspicua (the MIC(90) was 0.25 microg/ml and the minimum fungicidal concentration [MFC] was 0.5 microg/ml after 24 h). Total inhibition yielded falsely elevated MICs, exceeding even the respective MFCs.
摘要
测定了48株隐蔽念珠菌分离株对卡泊芬净的最低抑菌浓度和最低杀菌浓度。采用CLSI（原NCCLS）方法及部分抑制终点标准，卡泊芬净对隐蔽念珠菌显示出良好的杀菌效果（24小时后，MIC（90）为0.25微克/毫升，最低杀菌浓度[MFC]为0.5微克/毫升）。完全抑制导致MIC值假性升高，甚至超过各自的MFC值。
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