ME1036对耐甲氧西林金黄色葡萄球菌实验性诱导的心内膜炎的治疗效果。
Therapeutic effect of ME1036 on endocarditis experimentally induced by methicillin-resistant Staphylococcus aureus.
作者信息
Nagura Jun, Kijima Koji, Kurazono Mizuyo, Takahata Sho, Sugano Toshie, Tanaka Yukari, Hirai Yoko, Yamada Keiko, Takayama Yoshihiro, Shitara Eiki, Yonezawa Minoru
机构信息
Pharmaceutical Research Department, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan.
出版信息
Antimicrob Agents Chemother. 2005 Aug;49(8):3526-8. doi: 10.1128/AAC.49.8.3526-3528.2005.
Abstract
The efficacy of ME1036, a novel parenteral carbapenem, was compared with that of vancomycin by using a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA) endocarditis. Compared with vancomycin, ME1036 reduced the bacterial counts in the vegetations at a lower dosage or over a shorter period of administration when it was used for the treatment of MRSA endocarditis.
摘要
通过使用耐甲氧西林金黄色葡萄球菌（MRSA）心内膜炎的兔模型，将新型胃肠外注射用碳青霉烯类药物ME1036的疗效与万古霉素进行了比较。当用于治疗MRSA心内膜炎时，与万古霉素相比，ME1036以较低剂量或在较短给药期内降低了赘生物中的细菌数量。
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2
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Am Heart J. 2004 Mar;147(3):536-9. doi: 10.1016/j.ahj.2003.09.018.
3
Epidemiology of methicillin-resistant staphylococci in Europe.欧洲耐甲氧西林葡萄球菌的流行病学
Clin Microbiol Infect. 2003 Dec;9(12):1179-86. doi: 10.1111/j.1469-0691.2003.00698.x.
4
Infective endocarditis in adults.成人感染性心内膜炎
N Engl J Med. 2001 Nov 1;345(18):1318-30. doi: 10.1056/NEJMra010082.
5
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J Heart Valve Dis. 1998 Nov;7(6):672-707.
6
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7
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9
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