抗生素治疗对艰难梭菌在小鼠盲肠内容物中的生长及毒素产生的影响。
Effect of antibiotic treatment on growth of and toxin production by Clostridium difficile in the cecal contents of mice.
作者信息
Pultz Nicole J, Donskey Curtis J
机构信息
Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, 10701 East Blvd., Cleveland, OH 44106, USA.
出版信息
Antimicrob Agents Chemother. 2005 Aug;49(8):3529-32. doi: 10.1128/AAC.49.8.3529-3532.2005.
Abstract
In mice, subcutaneous administration of antibiotics that disrupt the anaerobic microflora (i.e., clindamycin, piperacillin-tazobactam, and ceftriaxone) facilitated in vitro growth of and toxin production by Clostridium difficile in cecal contents, whereas antibiotics that cause minimal disruption of the anaerobic microflora (i.e., levofloxacin, cefepime, and aztreonam) did not.
摘要
在小鼠中，皮下注射破坏厌氧微生物群的抗生素（即克林霉素、哌拉西林-他唑巴坦和头孢曲松）会促进艰难梭菌在盲肠内容物中的体外生长和毒素产生，而对厌氧微生物群破坏极小的抗生素（即左氧氟沙星、头孢吡肟和氨曲南）则不会。
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