采用等度高效液相色谱法并结合紫外检测，同时测定人血清中伏立康唑、伊曲康唑及其羟基代谢物的含量。
Isocratic high-performance liquid chromatographic method with ultraviolet detection for simultaneous determination of levels of voriconazole and itraconazole and its hydroxy metabolite in human serum.
作者信息
Khoschsorur GholamAli, Fruehwirth Franz, Zelzer Sieglinde
机构信息
Institute of Medical and Chemical Laboratory Diagnostics (LB.I), Auenbruggerplatz 29, A-8036 Graz, Austria.
出版信息
Antimicrob Agents Chemother. 2005 Aug;49(8):3569-71. doi: 10.1128/AAC.49.8.3569-3571.2005.
Abstract
A simple, specific method is presented for simultaneous determination of voriconazole and itraconazole and its metabolite, hydroxyitraconazole, in human serum using one-step liquid-liquid extraction and high-performance liquid chromatography. Linearity tests ranged from 0.1 to 8.0 microg/ml; the minimum detectable concentration was 0.03 microg/ml.
摘要
本文介绍了一种简单、特异的方法，采用一步液-液萃取和高效液相色谱法同时测定人血清中伏立康唑、伊曲康唑及其代谢产物羟基伊曲康唑。线性测试范围为0.1至8.0微克/毫升；最低检测浓度为0.03微克/毫升。
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