Müller P, Schmid K, Warnecke G, Setnikar I, Simon B
Gastroenterologische Abteilung, Medizinische Universitätsklinik Heidelberg, Bundesrepublik Deutschland.
Z Gastroenterol. 1992 Apr;30(4):252-4.
In a randomized double-blind study with two parallel groups of 10 male healthy volunteers each the response of gastric mucosa after a 7 days ingestion of sodium fluoride tablets (NaF) or sodium monofluorophosphate tablets (MFP) was compared. Gastroscopic evaluations were performed before treatment, day 1 and day 7. Simultaneously blood samples were collected for determination of laboratory data and serum fluoride values. In the MFP-group no severe gastric lesions were observed, whereas in the NaF-group in 7 of the 10 subjects significant gastric mucosal lesions including acute hemorrhages and free blood in the gastric lumen were found. The differences of the lesions scores in both groups were statistically significant (p = 0.0015). The serum fluoride content was comparable in both treatment groups. Possible adverse drug reactions were reported in 4 subjects with NaF and in 1 subject with MFP. In summary, under the experimental conditions used MFP is well tolerated by the stomach while NaF produces significant gastric mucosal lesions.
在一项随机双盲研究中，将两组各10名男性健康志愿者分为平行组，比较他们在摄入氟化钠片（NaF）或单氟磷酸钠片（MFP）7天后胃黏膜的反应。在治疗前、第1天和第7天进行胃镜评估。同时采集血样以测定实验室数据和血清氟含量。在MFP组未观察到严重的胃部病变，而在NaF组的10名受试者中，有7名发现了明显的胃黏膜病变，包括急性出血和胃腔内游离血液。两组病变评分的差异具有统计学意义（p = 0.0015）。两个治疗组的血清氟含量相当。4名服用NaF的受试者和1名服用MFP的受试者报告了可能的药物不良反应。总之，在所使用的实验条件下，MFP在胃中耐受性良好，而NaF会导致明显的胃黏膜病变。
