Greve Melissa, O'Connor Daniel
Broadmeadows Health Service, Melbourne, Australia.
Int Psychogeriatr. 2005 Jun;17(2):195-205. doi: 10.1017/s1041610205001481.
People with behavioral and psychological symptoms of dementia (BPSD) are often prescribed psychotropic medications. There is little evidence that one class of medication is more effective and safer than another and so expert opinion plays an important role in shaping local practice. In an earlier U.S. survey of psychiatrists and neurologists, limited consensus emerged regarding the pharmacological management of BPSD. We repeated this study to check consensus levels in Australia and New Zealand, following the introduction of newer atypical neuroleptics, antidepressants and cholinesterase inhibitors, and to identify areas where drug trials will be of greatest benefit.
A brief structured survey, similar to one used in the U.S.A., was posted to a random sample of members of the Australian and New Zealand Faculty of Psychiatry of Old Age.
We received 106 replies (71% response). Respondents, who had 14 years' experience on average, rated atypical neuroleptics as their treatment of choice for dementia complicated by psychosis, verbal aggression, physical aggression, sundowning and persistent yelling. Opinions varied widely regarding the management of other symptoms and the role of second-line treatments.
Atypical neuroleptics were preferred by most respondents for treatment of most BPSD. These views, while based on considerable clinical experience, have only limited backing from published reports, and head-to-head studies of available treatments are required to ensure that clinical practice has scientific support.
患有痴呆行为和心理症状(BPSD)的患者常被开具精神药物。几乎没有证据表明某一类药物比另一类更有效且更安全,因此专家意见在形成当地治疗方案中起着重要作用。在美国早期对精神科医生和神经科医生的调查中,关于BPSD的药物治疗仅达成了有限的共识。在引入更新的非典型抗精神病药、抗抑郁药和胆碱酯酶抑制剂之后,我们重复了这项研究,以检查澳大利亚和新西兰的共识水平,并确定药物试验将带来最大益处的领域。
向澳大利亚和新西兰老年精神病学学会成员的随机样本发放了一份简短的结构化调查问卷,该问卷与美国使用的问卷类似。
我们收到了106份回复(回复率为71%)。平均有14年经验的受访者将非典型抗精神病药列为治疗伴有精神病、言语攻击、身体攻击、日落综合征和持续喊叫的痴呆症的首选药物。对于其他症状的治疗以及二线治疗的作用,意见差异很大。
大多数受访者倾向使用非典型抗精神病药治疗大多数BPSD。这些观点虽然基于大量临床经验,但仅有有限的已发表报告支持,需要对现有治疗方法进行直接比较研究,以确保临床实践有科学依据。