Yokoyama Shohei, Tsutahara Kouichi, Fukuhara Shinichirou, Mori Naoki, Hara Tsuneo, Yamaguchi Seiji, Adachi Shirou
The Department of Urology, Ikeda Municipal Hospital.
Hinyokika Kiyo. 2005 Jun;51(6):403-5.
We report a case of primary small cell carcinoma of the urinary bladder. A 74-year-old woman was referred to our hospital because of pollakiuria. Cystoscopy showed a papillary tumor. We operated transurethral resection of the bladder tumor (TUR-Bt). Histopathological finding was transitional cell carcinoma (TCC), grade3, pT1 containing pTis. About six months later, tumor recurred to the bladder. Pathologic diagnosis was TCC in part and most was small cell carcinoma. Pelvic magnetic resonance imaging revealed a huge mass lesion with extravesical extension in the urinary bladder, and computed tomography scan showed external iliac lympho node metastasis. The rapid rise of a tumor maker NSE and pro-GRP were remarkable. It was diagnosed as a rapid advance of small cell carcinoma. We performed pelvic radiotherapy, and chemotherapy using carboplatin (CBDCA) and etoposide (VP-16). However 14 months after it had left hospital, computed tomography showed paraaortic lympho node metastasis. The patient died due to rapidly progressive disease.
我们报告一例原发性膀胱小细胞癌。一名74岁女性因尿频被转诊至我院。膀胱镜检查发现一个乳头状肿瘤。我们实施了经尿道膀胱肿瘤切除术（TUR-Bt）。组织病理学检查结果为移行细胞癌（TCC），3级，pT1包含pTis。大约六个月后，肿瘤复发至膀胱。病理诊断部分为TCC，大部分为小细胞癌。盆腔磁共振成像显示膀胱内有一个巨大的肿块病变并向膀胱外扩展，计算机断层扫描显示髂外淋巴结转移。肿瘤标志物NSE和pro-GRP迅速升高显著。诊断为小细胞癌快速进展。我们进行了盆腔放疗，并使用卡铂（CBDCA）和依托泊苷（VP-16）进行化疗。然而出院14个月后，计算机断层扫描显示腹主动脉旁淋巴结转移。患者因疾病快速进展死亡。
