Smith Joanne M, Rao Srinivas S, Stump Kyle C, Benazzi Cinzia, Sarli Giuseppe, DeTolla Louis J
NIH/OD/ORS/DVR, 9000 Rockville Pike, Bldg.14F, Rm.101, Bethesda, Maryland 20892, USA.
Contemp Top Lab Anim Sci. 2005 Jul;44(4):29-33.
A 23-year-old female rhesus macaque presented with a 2.5-cm diameter, firm, moveable, lobulated subcutaneous mass associated with a supranummary teat on the right side of the chest. This animal was a retired breeder, currently in an aging study. No exogenous hormone treatments were noted in the animal's history. Chest radiographs were within normal limits. Blood screens showed no noteworthy variations from normal. Needle aspirate cytology showed clusters of neoplastic cells. Grossly the mass was well circumscribed, firm, and homogeneously tan, with a glandular appearance. Differential diagnoses included sebaceous or mammary adenoma, carcinoma in situ, and lobular or ductular carcinoma. Histopathology was consistent with a mammary ductal carcinoma with comedo pattern. Subsequent needle aspirate cytology from an adjacent right axillary lymph node showed tumor cells with a few lymphoid cells, interpreted as lymphatic spread. Chest radiographs 2 and 6 weeks postbiopsy showed no evidence of pulmonary metastasis. After 1 year, there was no marked change on chest radiographs, but a small cluster of new nodules was palpable in the right axillary region. Histopathology of an excisional biopsy of the new nodules indicated tumor growth subjacent to regional lymph nodes. Further treatment was not performed and the animal remained clinically normal five years after the initial diagnosis. Spontaneous mammary neoplasia is a major concern in human medicine, yet it rarely has been reported to occur in nonhuman primates. This case is important in documenting an additional case of spontaneous mammary tumor development.
一只23岁的雌性恒河猴右侧胸部出现一个直径2.5厘米、质地坚硬、可移动、分叶状的皮下肿块，伴有一个乳头上方的乳头。这只动物是一只退役繁殖猴，目前正在进行衰老研究。动物病史中未发现外源性激素治疗。胸部X光片正常。血液检查未显示与正常情况有显著差异。针吸细胞学检查显示有肿瘤细胞团。大体上，肿块边界清晰、质地坚硬，呈均匀的棕褐色，有腺样外观。鉴别诊断包括皮脂腺腺瘤或乳腺腺瘤、原位癌以及小叶癌或导管癌。组织病理学结果符合粉刺型乳腺导管癌。随后对右侧腋窝旁淋巴结进行针吸细胞学检查，发现肿瘤细胞伴有少量淋巴细胞，提示有淋巴转移。活检后2周和6周的胸部X光片未显示肺转移迹象。1年后，胸部X光片无明显变化，但右侧腋窝区域可触及一小簇新结节。对新结节进行切除活检的组织病理学检查表明肿瘤在区域淋巴结下方生长。未进行进一步治疗，该动物在最初诊断后5年临床情况仍正常。自发性乳腺肿瘤在人类医学中是一个主要问题，但在非人灵长类动物中很少有报道。该病例对于记录另一例自发性乳腺肿瘤的发生具有重要意义。
