Mazzocco M M, Hagerman R J, Pennington B F
University of Colorado Health Sciences Center, Children's Hospital, Denver 80218-1088.
Am J Med Genet. 1992;43(1-2):78-86. doi: 10.1002/ajmg.1320430112.
Neurocognitive deficits among fragile X individuals have been reported for both high and low functioning individuals. Recent findings from our research suggest a specific neurocognitive phenotype among fragile X women that is characterized by deficits on tests of frontal lobe functioning. In this paper, we examine in more detail the performance of 10 cytogenetically expressing women and 10 control women on 2 problem solving measures considered sensitive to frontal lobe functions: the Contingency Naming Test and the Tower of Hanoi. The results pertaining to each test suggest that fragile X women, relative to control women, are less able to solve a problem when the difficulty of the problem is increased by requiring simultaneous consideration of additional information. These findings have important implications for remediation strategies designed for affected fragile X individuals.
脆性X综合征患者中，无论是高功能还是低功能个体，均有神经认知缺陷的报道。我们研究的最新发现表明，脆性X综合征女性存在一种特定的神经认知表型，其特征是额叶功能测试存在缺陷。在本文中，我们更详细地研究了10名细胞遗传学确诊的女性和10名对照女性在两项被认为对额叶功能敏感的问题解决测试中的表现：偶然性命名测试和河内塔测试。与每项测试相关的结果表明，相对于对照女性，当通过要求同时考虑额外信息来增加问题难度时，脆性X综合征女性解决问题的能力较差。这些发现对为受影响的脆性X综合征个体设计的补救策略具有重要意义。
