口腔黏膜良性淋巴组织增生症的特征
Characteristics of benign lymphoadenosis of oral mucosa.
作者信息
Li Shu-Xia, Yu Shi-Feng, Sun Kai-Hua
机构信息
Department of Oral Pathology, School of Stomatology, Peking University, Beijing 100081, China.
出版信息
World J Gastroenterol. 2005 Aug 7;11(29):4536-40. doi: 10.3748/wjg.v11.i29.4536.
AIM
To investigate the pathological characteristics and carcinogenesis mechanism of benign lymphoadenosis of oral mucosa (BLOM).
METHODS
The expressions of Ki-67, CD34 and apoptosis were evaluated by immunohistochemical SP staining in 64 paraffin-embedded tissue samples. Of them, 9 were from BLOM with dysplasia, 15 from BLOM without dysplasia, 15 from oral squamous cell carcinoma (OSCC), 15 from oral precancerosis, and 10 from normal tissues. Cell proliferation, apoptosis and angiogenesis of tissue samples were also analyzed.
RESULTS
The expression of Ki-67 in BLOM with dysplasia, oral precancerosis and OSCC was significantly higher than in BLOM without dysplasia and normal mucosa. The microvascular density (MVD) in BLOM with and without dysplasia, oral precancerosis, and OSCC was significantly higher than in normal mucosa. Apoptosis in BLOM and oral precancerosis was significantly higher than in OSCC and normal mucosa.
CONCLUSION
Benign lymphoadenosis of oral mucosa has potentialities of cancerization.
目的
探讨口腔黏膜良性淋巴组织增生症（BLOM）的病理特征及癌变机制。
方法
采用免疫组织化学SP法检测64例石蜡包埋组织标本中Ki-67、CD34的表达及凋亡情况。其中，9例来自伴发育异常的BLOM，15例来自无发育异常的BLOM，15例来自口腔鳞状细胞癌（OSCC），15例来自口腔癌前病变，10例来自正常组织。同时分析组织标本的细胞增殖、凋亡及血管生成情况。
结果
伴发育异常的BLOM、口腔癌前病变及OSCC中Ki-67的表达明显高于无发育异常的BLOM及正常黏膜。有发育异常和无发育异常的BLOM、口腔癌前病变及OSCC的微血管密度（MVD）明显高于正常黏膜。BLOM及口腔癌前病变中的凋亡明显高于OSCC及正常黏膜。
结论
口腔黏膜良性淋巴组织增生症具有癌变潜能。
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