信号传导与内吞作用：细胞迁移的协同作用

Signaling and endocytosis: a team effort for cell migration.

作者信息

Le Roy Christine, Wrana Jeffrey L

机构信息

Center for Systems Biology, Department of Medical Genetics and Microbiology, University of Toronto, Canada

出版信息

Dev Cell. 2005 Aug;9(2):167-8. doi: 10.1016/j.devcel.2005.07.007.

DOI:10.1016/j.devcel.2005.07.007

PMID:16054022

Abstract

Cellular movement from one place to another is regulated by various guidance cues. The precise perception of these signals in the three-dimensional environment of a multicellular organism is remarkably complex. Recent work is now revealing that guided cell movement also requires spatial control of signaling events by endocytic dynamics.

摘要

细胞从一个地方移动到另一个地方受到各种引导线索的调节。在多细胞生物体的三维环境中精确感知这些信号非常复杂。最近的研究表明，引导细胞运动还需要通过内吞动力学对信号事件进行空间控制。