Emery Gregory, Knoblich Juergen A
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Dr Bohr Gasse 3, 1030 Vienna, Austria.
Curr Opin Cell Biol. 2006 Aug;18(4):407-15. doi: 10.1016/j.ceb.2006.06.009. Epub 2006 Jun 27.
Endocytosis has traditionally been studied in isolated cells. More recently, however, the analysis of protein trafficking in whole organisms has revealed that it plays exciting roles during development. Endocytic trafficking of cell adhesion molecules regulates epithelial polarity and cell migration. Developmental signaling pathways are regulated by the trafficking of receptors and their ligands through the endocytic pathway. Finally, impairment of the endocytic machinery can affect proliferation control and contribute to tumor development.
传统上，内吞作用是在分离的细胞中进行研究的。然而，最近对整个生物体中蛋白质运输的分析表明，它在发育过程中发挥着令人兴奋的作用。细胞粘附分子的内吞运输调节上皮极性和细胞迁移。发育信号通路通过受体及其配体通过内吞途径的运输来调节。最后，内吞机制的损伤会影响增殖控制并促进肿瘤发展。
