超大号苍蝇。

Super-size flies.

作者信息

Kulkarni Meghana M, Perrimon Norbert

机构信息

Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School. Boston, Massachusetts 02115, USA.

出版信息

Cell Metab. 2005 May;1(5):288-90. doi: 10.1016/j.cmet.2005.04.008.

DOI:10.1016/j.cmet.2005.04.008

PMID:16054074

Abstract

The increasing prevalence of obesity and other nutrition-related chronic diseases has prompted considerable efforts to understand their pathogenesis and treatment. One experimental approach is to overexpress, inactivate, or manipulate specific genes that regulate energy metabolism and fat storage. Many such techniques are fully established, routine tools in Drosophila and C. elegans, which provide elegant models for dissecting endocrine problems and metabolic pathways.

摘要

肥胖及其他与营养相关的慢性疾病患病率不断上升，促使人们付出巨大努力去了解其发病机制和治疗方法。一种实验方法是过表达、失活或操纵调控能量代谢和脂肪储存的特定基因。许多此类技术在果蝇和秀丽隐杆线虫中已完全确立，是常用工具，它们为剖析内分泌问题和代谢途径提供了出色的模型。