Häder Thomas, Müller Sandra, Aguilera Miguel, Eulenberg Karsten G, Steuernagel Arnd, Ciossek Thomas, Kühnlein Ronald P, Lemaire Lydia, Fritsch Rüdiger, Dohrmann Cord, Vetter Ingrid R, Jäckle Herbert, Doane Winifred W, Brönner Günter
DeveloGen AG, Rudolf-Wissell-Strasse 28, 37079 Göttingen, Germany.
EMBO Rep. 2003 May;4(5):511-6. doi: 10.1038/sj.embor.embor837.
Obesity is a metabolic disorder related to improper control of energy uptake and expenditure, which results in excessive accumulation of body fat. Initial insights into the genetic pathways that regulate energy metabolism have been provided by a discrete number of obesity-related genes that have been identified in mammals. Here, we report the identification of the adipose (adp) gene, the mutation of which causes obesity in Drosophila. Loss of adp activity promotes increased fat storage, which extends the lifespan of mutant flies under starvation conditions. By contrast, adp gain-of-function causes a specific reduction of the fat body in Drosophila. adp encodes an evolutionarily conserved WD40/tetratricopeptide-repeat-domain protein that is likely to represent an intermediate in a novel signalling pathway.
肥胖是一种与能量摄取和消耗控制不当相关的代谢紊乱，会导致体内脂肪过度堆积。在哺乳动物中已鉴定出一些与肥胖相关的基因，这为调控能量代谢的遗传途径提供了初步见解。在此，我们报告了脂肪（adp）基因的鉴定，该基因的突变会导致果蝇肥胖。adp活性丧失会促进脂肪储存增加，这在饥饿条件下延长了突变果蝇的寿命。相比之下，adp功能获得则导致果蝇脂肪体特异性减少。adp编码一种进化上保守的WD40/四肽重复结构域蛋白，它可能代表一条新信号通路中的一个中间体。
